四川农业大学水稻所特邀学术报告

学术报告

题目：PlantmicroRNAs: biogenesis, degradation and modes of action

报告人：陈雪梅

报告人简介：

陈雪梅教授1995年获康奈尔大学理学博士学位。

1995-1998年加州理工学院进行博士后研究。

1999-2005年任罗格斯大学助理教授。

2005-2010加州大学河滨分校副教授、教授。

2011年入选霍华德休斯医学研究所学者（HHMI）。

2013年被评为美国国家科学院院士。

陈雪梅教授长期致力于植物sRNA和花器官发育研究，在Cell、Nature和Science等著名刊物发表多篇高水平论文，为解析植物sRNA及顶端分生组织发育的分子机制和生物学功能方面做了巨大贡献。

地点：一教309教室

时间：2014年7月11号(星期五)上午9：30

代表性文章:

1. Xigang Liu*,Lei Gao, Thanh Theresa Dinh, Ting Shi, Dongming Li, Ruozhong Wang, Lin Guo,Langtao Xiao,and Xuemei Chen*. (2014). DNA topoisomerase I impacts PolycombGroup protein-mediated epigenetic regulation and plant development by reducingnucleosome density in Arabidopsis. Plant Cell, in press.

2. Thanh TheresaDinh, Lei Gao, Xigang Liu, Dongming Li, Shengben Li, Yuanyuan Zhao, MichaelO’Leary, Brandon Le, Detlef Weigel, Olga Pontes, Joseph R. Ecker, and XuemeiChen*. (2014). DNA Topoisomerase 1αpromotes transcriptional silencing oftransposable elements through DNA methylation and histone lysine 9dimethylation in Arabidopsis. Plos Genetics.

3. Guodong Ren,Meng Xie, Shuxin Zhang, Carissa Vinovskis, Xuemei Chen*, and Bin Yu*. (2014).Methylation protects microRNAs from an AGO1-associated activity that uridylates5′RNAfragments generated by AGO1 cleavage. PNAS 111, 6365-6370.

4. Shengben Li,Lin Liu, Xiaohong Zhuang, Yu Yu, Xigang Liu, Xia Cui, Lijuan Ji, Zhiqiang Pan,Xiaofeng Cao, Beixin Mo, Fuchun Zhang, Natasha Raikhel, Liwen Jiang, and XuemeiChen*. (2013). microRNAs inhibit the translation of target mRNAs on the endoplasmicreticulum in Arabidopsis. Cell

5. BinglianZheng, Zhengming Wang, Shengben Li, Bin Yu, Jin-Yuan Liu, and Xuemei Chen*.(2009). Intergenic transcription by RNA polymerase II coordinates Pol IV andPol V in siRNA-directed transcriptional gene silencing in Arabidopsis. Genes& Dev. 23, 2850-2860.

6. VanitharaniRamachandran and Xuemei Chen*. (2008). Degradation of microRNAs by a family ofexoribonucleases in Arabidopsis. Science 321, 1490-1492.

7. Bin Yu,Zhiyong Yang, Junjie Li, Svetlana Minakhina, Maocheng Yang, Richard W. Padgett,Ruth Steward, and Xuemei Chen*. (2005). Methylation as a crucial step in plantmicroRNA biogenesis. Science 307, 932-935

8. Xuemei Chen*.(2004). A microRNA as a translational repressor of APETALA2 in Arabidopsisflower development. Science 303, 2022-2025.

主办单位：四川农业大学水稻研究所