Complete Genome Sequence of Bacillus thuringiensis serovar coreanensis ST7 with toxicity to human cancer cells

Jing zhang, Yiping liu, Rui Liu, Xu Liu, Baoli Zhang, Jun Zhu*

Advances in Microbiology，2020，10, 673-680

https://www.scirp.org/journal/paperinformation.aspx?paperid=106023

Abstract

Bacillus thuringiensis (Bt) parasporal crystal proteins were well known to be toxic to certain insects and cytocidal activity against various human cancer cells. Bt serovar coreanensis ST7, non-pathogenic to insects and non-hemolytic, has an important parasporin, PS4Aa1 (Cry45Aa1), with potential toxicity to human cancer cells. In this study, we reported the feature of complete genome sequence and the cluster of orthologous groups of proteins function classification of ST7. Meanwhile, the evolutionary of ST7 was also studied. The genome data of ST7 will strongly contribute to a better understanding of the genomic diversity and evolution, and enrich the Bt genome database.